ABSTRACT
Analisar as tendências das doações de sangue no Hemocentro do Estado de Goiás (HEMOGO), Brasil, considerando as campanhas de incentivo e as infecções transmissíveis por transfusão. Estudo retrospectivo das doações de sangue entre 2010-2016. Os doadores foram agrupados em categorias autóloga, voluntária, de reposição e de campanha. Houve 149.983 doações com redução de 29% (p <0,05). As doações por homens, com idade entre 18 e 29 anos e com menor escolaridade diminuíram (p <0,05) ao longo do tempo. Quase 50% das doações eram da categoria voluntária, 30% de campanha, 18% de reposição e 1% de outras categorias. As doações da campanha diminuíram 5,02% (p <0,05) entre 2010 a 2016. A prevalência de infecções transmitidas por transfusão (ITT) foi de 3,71% e a chance de doadores de campanha terem ITT foi menor (OR = 0,8628; IC: 0,8126 - 0,9161; p <0,0001). Os resultados mostraram uma redução nas doações de sangue, influenciadas principalmente por uma diminuição nas doações da campanha.
To analyze the trends of blood donations in a public blood center of Goias, Brazil (HEMOGO Hemocentro do Estado de Goiás), considering incentive campaigns and transfusion transmissible infection. Retrospective study of the blood donations between 2010-2016. Donors were grouped into autologous, voluntary, replacement and campaign categories. There were 149,983 donations with a reduction of 29% (p<0.05) in the investigated period. Donations by males, aging between 18 and 29 years old, and those with a lower level of education decreased (p<0.05) over time. Almost 50% of donations were from the voluntary category, 30% from campaing, 18% from replacement and 1% from other categories. The campaign donations decreased 5.02% (p<0.05) during the 2010 to 2016. The prevalence of transfusion-transmitted infections (TTI) was 3.71% and the chance of campaign donors having TTI was lower (OR = 0.8628; CI: 0.8126 - 0.9161; p<0.0001). The results showed a significant reduction in the number of blood donations mainly influenced by a decrease in campaign donations.
ABSTRACT
ABSTRACT Background: Assessing trends in the rate of transfusion-transmissible infections (TTIs) in blood donors is critical to the monitoring of the blood supply safety and the donor screening effectiveness. The objective of this study was to conduct a trend analysis of TTIs and associated demographic factors of donors at a public blood bank in the central Brazil. Methods: A retrospective analysis (2010-2016) of blood donation data was performed to determine the prevalence of markers for TTIs. Multinomial and multivariate logistic regression were used to verify the association between the explanatory variables and TTIs. The trend was evaluated with the Prais Winsten's regression analysis. Results: The prevalence of TTIs was 4.04% (5,553 donors) among 137,209 donors, with a steady trend in the analyzed period. The seroprevalence for the hepatitis B virus (HBV), syphilis, hepatitis C virus (HCV), human immunodeficiency virus (HIV), Chagas disease, and human T-lymphotropic virus (HTLV) were 1.63%, 0.87%, 0.46%, 0.21%, 0.21% and 0.09%, respectively. The prevalence of HBV decreased (b = −0.021, p < 0.001), while syphilis increased (b = 0.112; p = 0.001), during the period investigated. The probability for a positive test for TTI was higher among donors with a low level of education, aged ≥30 years old, without stable marital status, and first-time donors. Conclusions: Even with the reduction in HBV, the increased rate of syphilis may have contributed to the fact that the overall rate of TTIs did not decrease in the evaluated period.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Blood Transfusion , Epidemiology , Blood Safety , Transfusion Medicine , Blood-Borne InfectionsABSTRACT
ABSTRACT Background: Unexpected red blood cell alloantibodies can cause hemolytic transfusion reactions. In this study, the prevalence of alloimmunization, the rate of identification of alloantibodies and the rate of blood transfusion reactions among transfused patients were identified in a clinical emergency hospital in Brazil. Methods: Transfusions and clinical records of patients who had a positive indirect antiglobulin test between January and December 2013 were analyzed. Results: Of 1169 patients who received blood transfusions, 28 had positive indirect antiglobulin tests, with one patient having two positive tests at different times, resulting in 29 positive tests during the period of this study. Alloantibodies were identified in 58.6% (17/29) of the cases. In 27.5% (8/29), identification was inconclusive and it was not possible to confirm alloimmunization. The rate of red blood cell alloimmunization was 1.71% (21/1169). Of 21 cases of alloimmunization, four (19%) were unidentified due to an unusual agglutination profile. All identified alloantibodies were clinically significant (10/17 anti-Rh, 5/17 anti-Kell and 2/17 anti-MNS). In two patients who had positive indirect antiglobulin tests, one had an unidentified alloantibody, and the other had an inconclusive test and developed a hemolytic transfusion reaction. Conclusion: The prevalence of clinically important red blood cell alloantibodies and hemolytic transfusion reactions among patients with unidentified alloantibodies suggests that specific laboratory techniques should be performed to identify alloantibodies in cases of pan-reactivity or autoantibodies to improve transfusion safety.